TRANSFORM YOUR DRUG DISCOVERY
with Our Cell-Based Imaging Assays
Some of Our Imaging-Based Drug Discovery Capabilities
-
High Content Imaging (HCI), High Content Screening (HCS), High Content Analysis (HCA)
-
Immunofluorescence Microscopy
-
Target-Based and Phenotypic Screening
-
Fixed and Live-Cell imaging
-
Endpoint and Time-Lapse Imaging
Recently Completed Imaging-Based Drug Discovery Projects
-
Developed assays and conducted dose-response testing for drug effects on subcellular protein localization and quantification in 384-well format.
-
Developed assays and tested compounds in dose-response for inhibition of inflammasome priming, assembly and inflammatory cytokine release.
-
Identified cellular phenotypes in human iPSC-derived neurons associated with a disease mutation vs. normal control neurons. Evaluated compounds for rescue of mutant phenotype.
-
Completed calcium-imaging experiments in 14 cancer cell lines to determine whether a plasma membrane receptor was expressed for drug targeting.
-
Tested compounds for inhibition of phagocytosis.
-
Evaluated compounds for induction of apoptosis.
Other Services We Offer
-
Molecular & Cellular Biology Services: Western Blot, ELISA, Flow Cytometry, Cell-Line Development, etc.
-
Cell-Based Assay Development, Validation and Implementation in Microwell Formats
